Anti-GIMAP5 antibody (231-280 aa) (STJ93270)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GIMAP5 at the amino acid range 231-280
General Information
| Short Description | Rabbit polyclonal anti-GTPase IMAP family member 5 (231-280 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GIMAP5 |
| Gene ID | 55340 |
| Uniprot ID | GIMA5_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GIMAP5 at the amino acid range 231-280 |
| Immunogen Region | 231-280 aa |
| Specificity | GIMAP5 Polyclonal Antibody detects endogenous levels of GIMAP5 protein. |
Additional Info
| Function | Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes. Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function. May promote the survival of mature T lymphocytes upon cytokine withdrawal. May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation. May play a role in mitochondrial DNA segregation in hematopoietic tissues. Is a regulator of liver endothelial cell homeostasis. |
| Protein Name | Gtpase Imap Family Member 5Immune-Associated Nucleotide-Binding Protein 5Immunity-Associated Nucleotide 4-Like 1 ProteinImmunity-Associated Nucleotide 5 ProteinIan-5Hian5Immunity-Associated Protein 3 |
| Database Links | |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type Iv Membrane ProteinEndosomeMultivesicular Body MembraneEndosome MembraneThe Mitochondrial Localization Originally Reported Was Observed With C-Terminally Tagged Protein And Was Not Confirmed In Later Publications |
| Alternative Antibody Names | Anti-Gtpase Imap Family Member 5 antibodyAnti-Immune-Associated Nucleotide-Binding Protein 5 antibodyAnti-Immunity-Associated Nucleotide 4-Like 1 Protein antibodyAnti-Immunity-Associated Nucleotide 5 Protein antibodyAnti-Ian-5 antibodyAnti-Hian5 antibodyAnti-Immunity-Associated Protein 3 antibodyAnti-GIMAP5 antibodyAnti-IAN4L1 antibodyAnti-IAN5 antibodyAnti-IMAP3 antibody |
Information sourced from Uniprot.org