Anti-GDF9 antibody (273-322 aa) (STJ93256)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GDF-9 at the amino acid range 273-322
General Information
| Short Description | Rabbit polyclonal anti-Growth/differentiation factor 9 (273-322 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GDF9 |
| Gene ID | 2661 |
| Uniprot ID | GDF9_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GDF-9 at the amino acid range 273-322 |
| Immunogen Region | 273-322 aa |
| Specificity | GDF-9 Polyclonal Antibody detects endogenous levels of GDF-9 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated.phosphorylation is critical for GDF9 function. In vitro, can be phosphorylated by CK at Ser-325. |
| Function | Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. |
| Protein Name | Growth/Differentiation Factor 9Gdf-9 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Growth/Differentiation Factor 9 antibodyAnti-Gdf-9 antibodyAnti-GDF9 antibody |
Information sourced from Uniprot.org