| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GDAP1 |
| Gene ID: | 54332 |
| Uniprot ID: | GDAP1_HUMAN |
| Immunogen Region: | 1-225 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human GDAP1 (NP_001035808.1). |
| Immunogen Sequence: | MRLNSTGEVPVLIHGENIIC EATQIIDYLEQTFLDERTPR LMPDKESMYYPRVQHYRELL DSLPMDAYTHGCILHPELTV DSMIPAYATTRIRSQIGNTE SELKKLAEENPDLQEAYIAK QKRLKSKLLDHDNVKYLKKI LDELEKVLDQVETELQRRNE ETPEEGQQPWLCGESFTLAD VSLAVTLHRLKFLGFARRNW GNGKRPNLETYYERVLKRKT FNKVL |
| Tissue Specificity | Highly expressed in whole brain and spinal cord. Predominant expression in central tissues of the nervous system not only in neurons but also in Schwann cells. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Regulates the mitochondrial network by promoting mitochondrial fission. |
| Protein Name | Ganglioside-Induced Differentiation-Associated Protein 1Gdap1 |
| Database Links | Reactome: R-HSA-9603798 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane ProteinCytoplasm |
| Alternative Antibody Names | Anti-Ganglioside-Induced Differentiation-Associated Protein 1 antibodyAnti-Gdap1 antibodyAnti-GDAP1 antibody |
Information sourced from Uniprot.org