| Short Description : | Rabbit polyclonal anti-Glucagon receptor (95-144 aa) for use in WB, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:5000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GCGR |
| Gene ID: | 2642 |
| Uniprot ID: | GLR_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human GLR at the amino acid range 95-144 |
| Immunogen Region: | 95-144 aa |
| Specificity: | Glucagon Receptor Polyclonal Antibody detects endogenous levels of Glucagon Receptor protein. |
| Function | G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. |
| Protein Name | Glucagon ReceptorGl-R |
| Database Links | Reactome: R-HSA-163359Reactome: R-HSA-416476Reactome: R-HSA-418555Reactome: R-HSA-420092 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinIs Rapidly Internalized After Ligand-Binding |
| Alternative Antibody Names | Anti-Glucagon Receptor antibodyAnti-Gl-R antibodyAnti-GCGR antibody |
Information sourced from Uniprot.org
