| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GCGR (50-150) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GCGR |
| Gene ID: |
2642 |
| Uniprot ID: |
GLR_HUMAN |
| Immunogen Region: |
50-150 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human GCGR (NP_000151.1). |
| Immunogen Sequence: |
LPPPTELVCNRTFDKYSCWP DTPANTTANISCPWYLPWHH KVQHRFVFKRCGPDGQWVRG PRGQPWRDASQCQMDGEEIE VQKEVAKMYSSFQVMYTVGY S |
| Post Translational Modifications | Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding. |
| Function | G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. |
| Protein Name | Glucagon ReceptorGl-R |
| Database Links | Reactome: R-HSA-163359Reactome: R-HSA-416476Reactome: R-HSA-418555Reactome: R-HSA-420092 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinIs Rapidly Internalized After Ligand-Binding |
| Alternative Antibody Names | Anti-Glucagon Receptor antibodyAnti-Gl-R antibodyAnti-GCGR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
