| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GCAT |
| Gene ID: | 23464 |
| Uniprot ID: | KBL_HUMAN |
| Immunogen Region: | 170-419 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 170-419 of human GCAT (NP_055106.1). |
| Immunogen Sequence: | KAHKYRYRHLDMADLEAKLQ EAQKHRLRLVATDGAFSMDG DIAPLQEICCLASRYGALVF MDECHATGFLGPTGRGTDEL LGVMDQVTIINSTLGKALGG ASGGYTTGPGPLVSLLRQRA RPYLFSNSLPPAVVGCASKA LDLLMGSNTIVQSMAAKTQR FRSKMEAAGFTISGASHPIC PVMLGDARLASRMADDMLKR GIFVIGFSYPVVPKGKARIR VQISAVHSEEDIDRCVEAF |
| Tissue Specificity | Strongly expressed in heart, brain, liver and pancreas. Also found in lung. |
| Function | Pyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA. |
| Protein Name | 2-Amino-3-Ketobutyrate Coenzyme A Ligase - MitochondrialAkb LigaseAminoacetone SynthaseGlycine Acetyltransferase |
| Database Links | Reactome: R-HSA-8849175 |
| Cellular Localisation | MitochondrionNucleusTranslocates To The Nucleus Upon Cold And Osmotic Stress |
| Alternative Antibody Names | Anti-2-Amino-3-Ketobutyrate Coenzyme A Ligase - Mitochondrial antibodyAnti-Akb Ligase antibodyAnti-Aminoacetone Synthase antibodyAnti-Glycine Acetyltransferase antibodyAnti-GCAT antibodyAnti-KBL antibody |
Information sourced from Uniprot.org