| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GCA |
| Gene ID: | 25801 |
| Uniprot ID: | GRAN_HUMAN |
| Immunogen Region: | 1-217 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human GCA (NP_036330.1). |
| Immunogen Sequence: | MAYPGYGGGFGNFSIQVPGM QMGQPVPETGPAILLDGYSG PAYSDTYSSAGDSVYTYFSA VAGQDGEVDAEELQRCLTQS GINGTYSPFSLETCRIMIAM LDRDHTGKMGFNAFKELWAA LNAWKENFMTVDQDGSGTVE HHELRQAIGLMGYRLSPQTL TTIVKRYSKNGRIFFDDYVA CCVKLRALTDFFRKRDHLQQ GSANFIYDDFLQGTMAI |
| Tissue Specificity | Detected in neutrophils and macrophages (at protein level). Highly expressed in bone marrow. |
| Function | Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions. |
| Protein Name | Grancalcin |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmCytoplasmic Granule MembranePeripheral Membrane ProteinCytoplasmic SidePrimarily Cytosolic In The Absence Of Calcium Or Magnesium IonsRelocates To Granules And Other Membranes In Response To Elevated Calcium And Magnesium Levels |
| Alternative Antibody Names | Anti-Grancalcin antibodyAnti-GCA antibodyAnti-GCL antibody |
Information sourced from Uniprot.org