| Host: | Rabbit |
| Applications: | WB/IP/ELISA/ChIP/ChIP-seq |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S0MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:6000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.ChIP:5 Mu g ant |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GATA3 |
| Gene ID: | 2625 |
| Uniprot ID: | GATA3_HUMAN |
| Immunogen Region: | 1-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GATA3 (P23771). |
| Immunogen Sequence: | MEVTADQPRWVSHHHPAVLN GQHPDTHHPGLSHSYMDAAQ YPLPEEVDVLFNIDGQGNHV PPYYGNSVRATVQRYPPTHH GSQVCRPPLLHGSLPWLDGG KALGSHHTASPWNLSPFSKT SIHHGSPGPLSVYPPASSSS LSGGHASPHLFTFPPTPPKD VSPDPSLSTPGSAGSARQDE KECLKYQVPLPDSMKLESSH |
| Tissue Specificity | T-cells and endothelial cells. |
| Function | Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression. Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. |
| Protein Name | Trans-Acting T-Cell-Specific Transcription Factor Gata-3Gata-Binding Factor 3 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-6785807Reactome: R-HSA-8939236Reactome: R-HSA-9018519Reactome: R-HSA-9830364Reactome: R-HSA-983231 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Trans-Acting T-Cell-Specific Transcription Factor Gata-3 antibodyAnti-Gata-Binding Factor 3 antibodyAnti-GATA3 antibody |
Information sourced from Uniprot.org