| Post Translational Modifications | Highly phosphorylated on serine residues. Phosphorylation on Ser-310 is enhanced on erythroid differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137. Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation with SUMO1 has no effect on transcriptional activity. Acetylated at 2 conserved lysine-rich motifs by CREBBP in vitro. Acetylation does not affect DNA-binding in vitro but is essential to induce erythroid differentiation and for binding chromatin in vivo. Acetylated on Lys-233, Lys-245 Lys-246 by EP300. |
| Function | Transcriptional activator or repressor which serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-ATGATAAG-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. |
| Protein Name | Erythroid Transcription FactorEryf1Gata-Binding Factor 1Gata-1Gf-1Nf-E1 Dna-Binding Protein |
| Database Links | Reactome: R-HSA-8936459Reactome: R-HSA-8939236Reactome: R-HSA-983231 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Erythroid Transcription Factor antibodyAnti-Eryf1 antibodyAnti-Gata-Binding Factor 1 antibodyAnti-Gata-1 antibodyAnti-Gf-1 antibodyAnti-Nf-E1 Dna-Binding Protein antibodyAnti-GATA1 antibodyAnti-ERYF1 antibodyAnti-GF1 antibody |
Information sourced from Uniprot.org
