Anti-GARS antibody (43-289aa) [AT4E10] (STJA0041930)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human GARS (43-289aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-GARS (43-289aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT4E10 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GARS1 |
| Gene ID | 2617 |
| Uniprot ID | GARS_HUMAN |
| Accession Number | NP_002038 |
| Immunogen | Recombinant human GARS (43-289aa) purified from E. coli |
| Immunogen Region | 43-289aa |
Additional Info
| Tissue Specificity | Widely expressed, including in brain and spinal cord. Isoform 2: Expressed in brain, spinal cord, muscle, heart and spleen. Isoform 1: Expressed in brain, spinal cord, muscle, heart, spleen and liver. |
| Function | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. |
| Protein Name | Glycine--Trna LigaseDiadenosine Tetraphosphate SynthetaseAp4a SynthetaseGlycyl-Trna SynthetaseGlyrsGlycyl-Trna Synthetase 1 |
| Database Links | Reactome: R-HSA-379716Reactome: R-HSA-379726 |
| Cellular Localisation | CytoplasmCell ProjectionAxonSecretedExtracellular ExosomeIn Transfected Cos7 CellsNot Detected In MitochondriaNor In Golgi ApparatusSecreted By Motor NeuronPossibly Through The Exosome PathwayIsoform 1: MitochondrionIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Glycine--Trna Ligase antibodyAnti-Diadenosine Tetraphosphate Synthetase antibodyAnti-Ap4a Synthetase antibodyAnti-Glycyl-Trna Synthetase antibodyAnti-Glyrs antibodyAnti-Glycyl-Trna Synthetase 1 antibodyAnti-GARS1 antibodyAnti-GARS antibody |
Information sourced from Uniprot.org