| Short Description : | Sheep polyclonal anti-Gamma-synuclein (114-127) for use in IHC-F and WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-F/WB |
| Host: | Sheep |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | Affinity-purified |
| Dilution Range: | WB 2-5 µg/mLIHC 2-5 µg/mL |
| Storage Instruction: | Spin vial briefly before opening. Reconstitute in 20 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at-20°C for a higher stability, and at 2-8°C with an appropriate antibacterial |
| Gene Symbol: | SNCG |
| Gene ID: | 6623 |
| Uniprot ID: | SYUG_HUMAN |
| Immunogen: | A synthetic peptide (EKEEVAEEAQSGGD) as part of human gamma synuclein protein (114-127) conjugated to diphteria toxid has been used as the immunogen. |
| Immunogen Region: | 114-127 |
| Immunogen Sequence: | Human |
| Specificity: | Immunohistochemical/Western blot anlysis indicate a high level of specificity for this antiserum for gamma synuclein. This antiserum is known to react with human and rat gamma synuclein. |
| Tissue Specificity | Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. |
| Post Translational Modifications | Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. |
| Function | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. |
| Protein Name | Gamma-SynucleinBreast Cancer-Specific Gene 1 ProteinPersynSynoretinSr |
| Database Links | |
| Cellular Localisation | CytoplasmPerinuclear RegionCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleAssociated With Centrosomes In Several Interphase CellsIn Mitotic CellsLocalized To The Poles Of The Spindle |
| Alternative Antibody Names | Anti-Gamma-Synuclein antibodyAnti-Breast Cancer-Specific Gene 1 Protein antibodyAnti-Persyn antibodyAnti-Synoretin antibodyAnti-Sr antibodyAnti-SNCG antibodyAnti-BCSG1 antibodyAnti-PERSYN antibodyAnti-PRSN antibody |
Information sourced from Uniprot.org