| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | G2E3 |
| Gene ID: | 55632 |
| Uniprot ID: | G2E3_HUMAN |
| Immunogen Region: | 1-180 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human G2E3 (NP_060239.2). |
| Immunogen Sequence: | MNESKPGDSQNLACVFCRKH DDCPNKYGEKKTKEKWNLTV HYYCLLMSSGIWQRGKEEEG VYGFLIEDIRKEVNRASKLK CCVCKKNGASIGCVAPRCKR SYHFPCGLQRECIFQFTGNF ASFCWDHRPVQIITSNNYRE SLPCTICLEFIEPIPSYNIL RSPCCKNAWFHRDCLQVQAI |
| Tissue Specificity | Predominantly expressed in brain, liver, kidney, testes and ovary. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death. |
| Protein Name | G2/M Phase-Specific E3 Ubiquitin-Protein LigaseG2/M Phase-Specific Hect-Type E3 Ubiquitin Transferase |
| Cellular Localisation | NucleusNucleolusCytoplasmShuttles Between The Nucleus And The CytoplasmIn The NucleusDelocalizes From The Nucleolus To The Nucleoplasm In Response To Dna Damage |
| Alternative Antibody Names | Anti-G2/M Phase-Specific E3 Ubiquitin-Protein Ligase antibodyAnti-G2/M Phase-Specific Hect-Type E3 Ubiquitin Transferase antibodyAnti-G2E3 antibodyAnti-KIAA1333 antibody |
Information sourced from Uniprot.org