| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FZD9 (469-591) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FZD9 |
| Gene ID: |
8326 |
| Uniprot ID: |
FZD9_HUMAN |
| Immunogen Region: |
469-591 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 469-591 of human FZD9 (NP_003499.1). |
| Immunogen Sequence: |
ERLNMDFWRLRATEQPCAAA AGPGGRRDCSLPGGSVPTVA VFMLKIFMSLVVGITSGVWV WSSKTFQTWQSLCYRKIAAG RARAKACRAPGSYGRGTHCH YKAPTVVLHMTKTDPSLENP THL |
| Tissue Specificity | Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney. Expressed in neural progenitor cells. |
| Post Translational Modifications | Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. |
| Function | Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway. May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process. During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling. |
| Protein Name | Frizzled-9Fz-9Hfz9Fze6Cd Antigen Cd349 |
| Database Links | Reactome: R-HSA-373080 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinRelocalizes Dvl1 To The Cell Membrane Leading To Phosphorylation Of Dvl1 And Axin1 Relocalization To The Cell Membrane |
| Alternative Antibody Names | Anti-Frizzled-9 antibodyAnti-Fz-9 antibodyAnti-Hfz9 antibodyAnti-Fze6 antibodyAnti-Cd Antigen Cd349 antibodyAnti-FZD9 antibodyAnti-FZD3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
