| Host: |
Mouse |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-FYN-binding protein 1 is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
2H9-H6-G10 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FYB1 |
| Gene ID: |
2533 |
| Uniprot ID: |
FYB1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of FYB and does not cross-react with related proteins. |
| Immunogen: |
Purified recombinant human FYB protein fragments expressed in E.coli. |
| Post Translational Modifications | T-cell receptor ligation leads to increased tyrosine phosphorylation. |
| Function | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. Modulates the expression of IL2. Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. |
| Protein Name | Fyn-Binding Protein 1Adhesion And Degranulation Promoting Adaptor ProteinAdapFyb-120/130P120/P130Fyn-T-Binding ProteinSlap-130Slp-76-Associated Phosphoprotein |
| Database Links | Reactome: R-HSA-202433Reactome: R-HSA-391160 |
| Cellular Localisation | CytoplasmNucleusCell JunctionColocalizes With Tmem47 At Cell-Cell Contacts In Podocytes |
| Alternative Antibody Names | Anti-Fyn-Binding Protein 1 antibodyAnti-Adhesion And Degranulation Promoting Adaptor Protein antibodyAnti-Adap antibodyAnti-Fyb-120/130 antibodyAnti-P120/P130 antibodyAnti-Fyn-T-Binding Protein antibodyAnti-Slap-130 antibodyAnti-Slp-76-Associated Phosphoprotein antibodyAnti-FYB1 antibodyAnti-FYB antibodyAnti-SLAP130 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
