| Host: | Mouse |
| Applications: | WB/ICC/IP |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-FXYD5/Dysadherin (Extracellular region) is suitable for use in Western Blot, Immunocytochemistry and Immunoprecipitation research applications. |
| Clonality : | Monoclonal |
| Clone ID : | M031 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:500ICC 1:100IP 1:50 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FXYD5 |
| Gene ID: | 53827 |
| Uniprot ID: | FXYD5_HUMAN |
| Immunogen Region: | Extracellular region |
| Specificity: | Clone M031 mouse monoclonal antibody detects a 35-55 kDa* band on SDS-PAGE immunoblots of human A431, A549, MeWo, MDA-MB-231 cell, as well as human breast, lung, and skin tissues. The antibody works for western blot, immunoprecipitation, ELISA, and i |
| Immunogen: | Clone (M031) was generated from a proprietary antigen related to the native human FXYD5 protein expressed in MDA-MB-231 breast cancer cell line. |
| Post Translational Modifications | Glycosylated. |
| Function | Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. May increase NKA activity by increasing the apparent affinity for Na(+). Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. |
| Protein Name | Fxyd Domain-Containing Ion Transport Regulator 5Dysadherin |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinBasolateral Cell MembraneIn Kidneys Localizes To The Basolateral Membrane Of The Connecting Tubule |
| Alternative Antibody Names | Anti-Fxyd Domain-Containing Ion Transport Regulator 5 antibodyAnti-Dysadherin antibodyAnti-FXYD5 antibodyAnti-DYSAD antibodyAnti-IWU1 antibodyAnti-HSPC113 antibodyAnti-UNQ2561 antibodyAnti-PRO6241 antibody |
Information sourced from Uniprot.org