| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FXYD1 (1-92) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FXYD1 |
| Gene ID: |
5348 |
| Uniprot ID: |
PLM_HUMAN |
| Immunogen Region: |
1-92 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-92 of human FXYD1 (NP_005022.2). |
| Immunogen Sequence: |
MASLGHILVFCVGLLTMAKA ESPKEHDPFTYDYQSLQIGG LVIAGILFILGILIVLSRRC RCKFNQQQRTGEPDEEEGTF RSSIRRLSTRRR |
| Tissue Specificity | Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis. |
| Post Translational Modifications | Major plasma membrane substrate for cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation. Phosphorylation at Ser-88 stimulates sodium/potassium-transporting ATPase activity while the unphosphorylated form inhibits sodium/potassium-transporting ATPase activity. Phosphorylation increases tetramerization, decreases binding to ATP1A1 and reduces inhibition of ATP1A1 activity. Phosphorylation at Ser-83 leads to greatly reduced interaction with ATP1A1, ATP1A2 and ATP1A3. May be phosphorylated by DMPK. Palmitoylation increases half-life and stability and is enhanced upon phosphorylation at Ser-88 by PKA. |
| Function | Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. |
| Protein Name | PhospholemmanFxyd Domain-Containing Ion Transport Regulator 1Sodium/Potassium-Transporting Atpase Subunit Fxyd1 |
| Database Links | Reactome: R-HSA-5578775Reactome: R-HSA-936837Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneSarcolemmaSingle-Pass Type I Membrane ProteinApical Cell MembraneMembraneCaveolaT-TubuleDetected In The Apical Cell Membrane In BrainIn MyocytesLocalizes To SarcolemmaT-Tubules And Intercalated Disks |
| Alternative Antibody Names | Anti-Phospholemman antibodyAnti-Fxyd Domain-Containing Ion Transport Regulator 1 antibodyAnti-Sodium/Potassium-Transporting Atpase Subunit Fxyd1 antibodyAnti-FXYD1 antibodyAnti-PLM antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
