Anti-FUT6 antibody (STJA0007832)

SKU:
STJA0007832

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FUT6
Gene ID: 2528
Uniprot ID: FUT6_HUMAN
Specificity: This antibody detects endogenous levels of FUT6 at Human
Immunogen: Synthesized peptide derived from human FUT6
Post Translational Modifications N-glycosylated. Proteolytic cleavage releases a secreted glycoform of 43 kDa.
Function Isoform 1: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein- or a glycolipid-linked sialopolylactosamines chain or of a distal or internal lactosamine unit of a neutral glycoprotein- or a glycolipid-linked polylactosamines chain through an alpha-1,3 glycosidic linkage and participates in surface expression of the sialyl Lewis X (sLe(x)), Lewis X (Le(x)) and non sialylated VIM2 determinants. Moreover transfers fucose to H-type 2 (Fucalpha1-2Galbeta1-4GlcNAc) chain acceptor substrates and participates in difucosylated sialyl Lewis x determinants. Also fucosylates a polylactosamine substrate having a 6 sulfate modification at the GlcNAc moiety and gives rise to sialyl and non-sialyl 6-sulfo lewis X. Does not have activity towards type 1 ((Galbeta1-3GlcNAc)) and H-type 1 chain (Fucalpha1-2Galbeta1-3GlcNAc) acceptors substrates. Isoform 2: Does not have alpha(1,3)-fucosyltransferase activity.
Protein Name 4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase Fut6
Fucosyltransferase 6
Fucosyltransferase Vi
Fuc-Tvi
Fuct-Vi
Galactoside 3-L-Fucosyltransferase
Database Links Reactome: R-HSA-9037629
Cellular Localisation Golgi Apparatus
Golgi Stack Membrane
Single-Pass Type Ii Membrane Protein
Secreted
Membrane-Bound Form In Trans Cisternae Of Golgi
Alternative Antibody Names Anti-4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase Fut6 antibody
Anti-Fucosyltransferase 6 antibody
Anti-Fucosyltransferase Vi antibody
Anti-Fuc-Tvi antibody
Anti-Fuct-Vi antibody
Anti-Galactoside 3-L-Fucosyltransferase antibody
Anti-FUT6 antibody
Anti-FCT3A antibody

Information sourced from Uniprot.org

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