| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FTL |
| Gene ID: | 2512 |
| Uniprot ID: | FRIL_HUMAN |
| Immunogen Region: | 1-175 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human Ferritin Light Chain (NP_000137.2). |
| Immunogen Sequence: | MSSQIRQNYSTDVEAAVNSL VNLYLQASYTYLSLGFYFDR DDVALEGVSHFFRELAEEKR EGYERLLKMQNQRGGRALFQ DIKKPAEDEWGKTPDAMKAA MALEKKLNQALLDLHALGSA RTDPHLCDFLETHFLDEEVK LIKKMGDHLTNLHRLGGPEA GLGEYLFERLTLKHD |
| Function | Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Delivery to lysosomes by the cargo receptor NCOA4 for autophagic degradation and release or iron. |
| Protein Name | Ferritin Light Chain Ferritin L Subunit |
| Database Links | Reactome: R-HSA-3000480 Reactome: R-HSA-432722 Reactome: R-HSA-6798695 Reactome: R-HSA-917937 |
| Cellular Localisation | Cytoplasmic Vesicle Autophagosome Cytoplasm Autolysosome |
| Alternative Antibody Names | Anti-Ferritin Light Chain antibody Anti-Ferritin L Subunit antibody Anti-FTL antibody |
Information sourced from Uniprot.org