||WB, IF, ELISA
||Human, Mouse, Monkey
||Rabbit polyclonal anti-Frizzled-9 antibody is suitable for use in Western Blot, Immunofluorescence and ELISA.
||FOR RESEARCH USE ONLY (RUO).
||Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
||Store at-20°C, and avoid repeat freeze-thaw cycles.
||WB 1:500-1:2000IF 1:200-1:1000ELISA 1:20000
||Frizzled-9 polyclonal antibody detects endogenous levels of Frizzled-9 protein.
||Synthesized peptide derived from human Frizzled-9
||520-600 aa, C-terminal
| Post Translational Modifications || Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. |
| Function || Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway. May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process. During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling. |
| Protein Name || Frizzled-9Fz-9Hfz9Fze6Cd Antigen Cd349 |
| Database Links || Reactome: R-HSA-373080 |
| Cellular Localisation || Cell MembraneMulti-Pass Membrane ProteinRelocalizes Dvl1 To The Cell Membrane Leading To Phosphorylation Of Dvl1 And Axin1 Relocalization To The Cell Membrane |
| Alternative Antibody Names || Anti-Frizzled-9 antibodyAnti-Fz-9 antibodyAnti-Hfz9 antibodyAnti-Fze6 antibodyAnti-Cd Antigen Cd349 antibodyAnti-FZD9 antibodyAnti-FZD3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance