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Primary Antibodies
Polyclonal Antibodies
Anti-Frizzled-5/8 antibody (31-80 aa) (STJ93148)

Western blot analysis of lysates from Jurkat cells, using FZD8 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of the lysates from HUVECcells using FZD8 antibody.
Immunofluorescence analysis of A549 cells, using FZD8 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-Frizzled-5/8 antibody (31-80 aa) (STJ93148)

SKU:

STJ93148

£46.00 - £226.00

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Frizzled-5 and Frizzled-8 (31-80 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IF 1:200-1:1000 ELISA 1:20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FZD5 FZD8
Gene ID:	7855 8325
Uniprot ID:	FZD5_HUMAN FZD8_HUMAN
Immunogen Region:	31-80 aa
Specificity:	Frizzled-5/8 Polyclonal Antibody detects endogenous levels of Frizzled-5/8 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human FZD8 at the amino acid range 31-80

Function	Receptor for Wnt proteins. Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro).the in vivo situation may be different since not all of these are known to be coexpressed. In neurons, activation of WNT7A promotes formation of synapses. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization.
Protein Name	Frizzled-5 Fz-5 Hfz5 Fze5
Database Links	Reactome: R-HSA-373080 Reactome: R-HSA-4086398 Reactome: R-HSA-4608870 Reactome: R-HSA-4641262 Reactome: R-HSA-4641263 Reactome: R-HSA-5140745 Reactome: R-HSA-5340588
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Golgi Apparatus Membrane Cell Junction Synapse Perikaryon Cell Projection Dendrite Axon Localized At The Plasma Membrane And Also Found At The Golgi
Alternative Antibody Names	Anti-Frizzled-5 antibody Anti-Fz-5 antibody Anti-Hfz5 antibody Anti-Fze5 antibody Anti-FZD5 antibody Anti-C2orf31 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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