||WB, IF, ELISA
||Human, Mouse, Rat
||Rabbit polyclonal anti-Frizzled-2 antibody is suitable for use in Western Blot, Immunofluorescence and ELISA.
||FOR RESEARCH USE ONLY (RUO).
||Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
||Store at-20°C, and avoid repeat freeze-thaw cycles.
||WB 1:500-1:2000IF 1:200-1:1000ELISA 1:40000
||Frizzled-2 polyclonal antibody detects endogenous levels of Frizzled-2 protein.
||Synthesized peptide derived from human Frizzled-2
||180-260 aa, Internal
| Post Translational Modifications || Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. |
| Function || Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium. TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling. |
| Protein Name || Frizzled-2Fz-2Hfz2Fze2 |
| Database Links || Reactome: R-HSA-201681Reactome: R-HSA-373080Reactome: R-HSA-4086398Reactome: R-HSA-4608870Reactome: R-HSA-4641262Reactome: R-HSA-5140745 |
| Cellular Localisation || MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names || Anti-Frizzled-2 antibodyAnti-Fz-2 antibodyAnti-Hfz2 antibodyAnti-Fze2 antibodyAnti-FZD2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance