Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | FOXD3 |
Gene ID: | 27022 |
Uniprot ID: | FOXD3_HUMAN |
Immunogen Region: | 322-335 |
Specificity: | A synthetic peptide corresponding to a sequence within amino acids 322-335AA of human FOXD3. |
Tissue Specificity | Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. |
Function | Binds to the consensus sequence 5'-AATTAGTTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Negatively regulates transcription of transcriptional repressor RHIT/ZNF205. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. |
Protein Name | Forkhead Box Protein D3 Hnf3/Fh Transcription Factor Genesis |
Database Links | Reactome: R-HSA-2892247 Reactome: R-HSA-9856649 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Forkhead Box Protein D3 antibody Anti-Hnf3/Fh Transcription Factor Genesis antibody Anti-FOXD3 antibody Anti-HFH2 antibody |
Information sourced from Uniprot.org