| Tissue Specificity | Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain. |
| Function | May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. |
| Protein Name | Formin-Binding Protein 1Formin-Binding Protein 17Hfbp17 |
| Database Links | Reactome: R-HSA-8856828Reactome: R-HSA-9013148Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9696270 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexLysosomeCytoplasmic VesicleCell MembranePeripheral Membrane ProteinCytoplasmic SideMembraneClathrin-Coated PitEnriched In Cortical Regions Coincident With F-ActinAlso Localizes To Endocytic Vesicles And Lysosomes |
| Alternative Antibody Names | Anti-Formin-Binding Protein 1 antibodyAnti-Formin-Binding Protein 17 antibodyAnti-Hfbp17 antibodyAnti-FNBP1 antibodyAnti-FBP17 antibodyAnti-KIAA0554 antibody |
Information sourced from Uniprot.org
