| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Formin-2 (1541-1590 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FMN2 |
| Gene ID: |
56776 |
| Uniprot ID: |
FMN2_HUMAN |
| Immunogen Region: |
1541-1590 aa |
| Specificity: |
Formin 2 Polyclonal Antibody detects endogenous levels of Formin 2 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human FMN2 at the amino acid range 1541-1590 |
| Function | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. Protects cells against apoptosis by protecting CDKN1A against degradation. |
| Protein Name | Formin-2 |
| Cellular Localisation | CytoplasmCytoskeletonCytosolPerinuclear RegionNucleusNucleolusCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic Vesicle MembraneCell CortexColocalizes With The Actin CytoskeletonRecruited To The Membranes Via Its Interaction With Spire1Detected At The Cleavage Furrow During Asymmetric Oocyte Division And Polar Body ExtrusionAccumulates In The Nucleus Following Dna Damage |
| Alternative Antibody Names | Anti-Formin-2 antibodyAnti-FMN2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
