Anti-Phospho-Filamin B-2481 antibody (2450-2500) (STJ502440)

SKU:
STJ502440-100

Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Filamin B-2481 (2450-2500) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
IHC: 1:50-1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: FLNB
Gene ID: 2317
Uniprot ID: FLNB_HUMAN
Immunogen Region: 2450-2500
Immunogen: Synthetic peptide taken within amino acid region 2450-2500 on human Phospho-Filamin-B. Phosphorylated 2481 serine residue.
Tissue Specificity Ubiquitous. Isoform 1 and isoform 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells (HUVEC), retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord, platelet and Daudi cells. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer disease (AD). Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart.
Post Translational Modifications ISGylation prevents ability to interact with the upstream activators of the JNK cascade and inhibits IFNA-induced JNK signaling. Ubiquitination by a SCF-like complex containing ASB2 isoform 1 leads to proteasomal degradation which promotes muscle differentiation.
Function Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
Protein Name Filamin-B
Fln-B
Abp-278
Abp-280 Homolog
Actin-Binding-Like Protein
Beta-Filamin
Filamin Homolog 1
Fh1
Filamin-3
Thyroid Autoantigen
Truncated Actin-Binding Protein
Truncated Abp
Database Links Reactome: R-HSA-1169408
Cellular Localisation Isoform 1: Cytoplasm
Cell Cortex
Cytoplasm
Cytoskeleton
Stress Fiber
Myofibril
Sarcomere
Z Line
In Differentiating Myotubes
Isoform 1
Isoform 2 And Isoform 3 Are Localized Diffusely Throughout The Cytoplasm With Regions Of Enrichment At The Longitudinal Actin Stress Fiber
In Differentiated Tubes
Isoform 1 Is Also Detected Within The Z-Lines
Isoform 2: Cytoplasm
Isoform 3: Cytoplasm
Isoform 6: Cytoplasm
Polarized At The Periphery Of Myotubes
Alternative Antibody Names Anti-Filamin-B antibody
Anti-Fln-B antibody
Anti-Abp-278 antibody
Anti-Abp-280 Homolog antibody
Anti-Actin-Binding-Like Protein antibody
Anti-Beta-Filamin antibody
Anti-Filamin Homolog 1 antibody
Anti-Fh1 antibody
Anti-Filamin-3 antibody
Anti-Thyroid Autoantigen antibody
Anti-Truncated Actin-Binding Protein antibody
Anti-Truncated Abp antibody
Anti-FLNB antibody
Anti-FLN1L antibody
Anti-FLN3 antibody
Anti-TABP antibody
Anti-TAP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance