| Host: | Mouse |
| Applications: | Blocking/FC |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
| Short Description : | Mouse monoclonal antibody anti-Fibroblast Growth Factor 2 is suitable for use in Universaling and Flow Cytometry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | GAL-F2 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | 0.01M PBS |
| Purification: | Protein A/G purified from cell culture supernatant |
| Concentration: | 1 mg/mL |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
| Gene Symbol: | Fgf2 |
| Gene ID: | 14173 |
| Uniprot ID: | FGF2_MOUSE |
| Function | Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation. |
| Protein Name | Fibroblast Growth Factor 2Fgf-2Basic Fibroblast Growth FactorBfgfHeparin-Binding Growth Factor 2Hbgf-2 |
| Database Links | Reactome: R-MMU-109704Reactome: -MMU-1257604Reactome: -MMU-190322Reactome: -MMU-190370Reactome: -MMU-190372Reactome: -MMU-190373Reactome: -MMU-190375Reactome: -MMU-190377Reactome: -MMU-3000170Reactome: -MMU-5654219Reactome: -MMU-5654221Reactome: -MMU-5654227Reactome: -MMU-5654228Reactome: -MMU-5654687Reactome: -MMU-5654688Reactome: -MMU-5654689Reactome: -MMU-5654693Reactome: -MMU-5654695Reactome: -MMU-5654699Reactome: -MMU-5654700Reactome: -MMU-5654704Reactome: -MMU-5654706Reactome: -MMU-5654710Reactome: -MMU-5654712Reactome: -MMU-5654719Reactome: -MMU-5654720Reactome: -MMU-5654726Reactome: -MMU-5654727Reactome: -MMU-5654732Reactome: -MMU-5654733Reactome: -MMU-5658623Reactome: -MMU-5673001Reactome: -MMU-6811558Reactome: -MMU-9839397 |
| Cellular Localisation | SecretedNucleusExported From Cells By An Endoplasmic Reticulum (Er)/Golgi-Independent MechanismUnconventional Secretion Of Fgf2 Occurs By Direct Translocation Across The Plasma MembraneBinding Of Exogenous Fgf2 To Fgfr Facilitates Endocytosis Followed By Translocation Of Fgf2 Across Endosomal Membrane Into The CytosolNuclear Import From The Cytosol Requires The Classical Nuclear Import MachineryInvolving Proteins Kpna1 And Kpnb1As Well As Cep57 |
| Alternative Antibody Names | Anti-Fibroblast Growth Factor 2 antibodyAnti-Fgf-2 antibodyAnti-Basic Fibroblast Growth Factor antibodyAnti-Bfgf antibodyAnti-Heparin-Binding Growth Factor 2 antibodyAnti-Hbgf-2 antibodyAnti-Fgf2 antibodyAnti-Fgf-2 antibody |
Information sourced from Uniprot.org