| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Fas apoptotic inhibitory molecule 3 (123-173 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FCMR |
| Gene ID: |
9214 |
| Uniprot ID: |
FCMR_HUMAN |
| Immunogen Region: |
123-173 aa |
| Specificity: |
This antibody detects endogenous levels of FAIM3 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human FAIM3 at the amino acid range 123-173 |
| Post Translational Modifications | Phosphorylated on both Tyr and Ser residues. O-glycosylated. Sialylated. O-linked glycans regulate trafficking to the plasma membrane. |
| Function | High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM. Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues. Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways. |
| Protein Name | Immunoglobulin Mu Fc ReceptorIgm FcrFas Apoptotic Inhibitory Molecule 3Faim3Regulator Of Fas-Induced Apoptosis Toso |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEarly Endosome MembraneGolgi ApparatusTrans-Golgi Network MembraneLysosome MembraneContinuously Recycles Between Cytoplasmic Pool And The Plasma Membrane To Bind As Much Igm As PossibleIsoform 3: SecretedDetected In The Serum |
| Alternative Antibody Names | Anti-Immunoglobulin Mu Fc Receptor antibodyAnti-Igm Fcr antibodyAnti-Fas Apoptotic Inhibitory Molecule 3 antibodyAnti-Faim3 antibodyAnti-Regulator Of Fas-Induced Apoptosis Toso antibodyAnti-FCMR antibodyAnti-FAIM3 antibodyAnti-TOSO antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
