| Tissue Specificity | Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow. |
| Post Translational Modifications | Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization. Phosphorylation at Thr-419 and Ser-480 in absence of stress promotes its ubiquitination and degradation by the SCF(FBXO46) complex. Phosphorylation at Ser-33 by AKT1 promotes association with CDC20 and ubiquitination by the APC/C complex. Ubiquitinated by the SCF(FBXO46) complex in absence of stress, promoting its degradation. Ubiquitinated by the APC/C complex following phosphorylation at Ser-33, leading to its degradation by the proteasome. |
| Function | Substrate-recognition component of the SCF(FBXO31) protein ligase complex, which specifically mediates the ubiquitination of proteins amidated at their C-terminus in response to oxidative stress, leading to their degradation by the proteasome. FBXO31 specifically recognizes and binds C-terminal peptides bearing an amide: C-terminal amidation in response to oxidative stress takes place following protein fragmentation. The SCF(FBXO31) also plays a role in G1 arrest following DNA damage by mediating ubiquitination of phosphorylated cyclin-D1 (CCND1), promoting its degradation by the proteasome, resulting in G1 arrest. The SCF(FBXO31) complex is however not a major regulator of CCND1 stability during the G1/S transition. In response to genotoxic stress, the SCF(FBXO31) complex directs ubiquitination and degradation of phosphorylated MDM2, thereby promoting p53/TP53-mediated DNA damage response. SCF(FBXO31) complex is required for genomic integrity by catalyzing ubiquitination and degradation of cyclin-A (CCNA1 and/or CCNA2) during the G1 phase. In response to genotoxic stress, the SCF(FBXO31) complex directs ubiquitination and degradation of phosphorylated FBXO46 and MAP2K6. SCF(FBXO31) complex promotes ubiquitination and degradation of CDT1 during the G2 phase to prevent re-replication. The SCF(FBXO31) complex also mediates ubiquitination and degradation of DUSP6, OGT and PARD6A. |
| Protein Name | F-Box Only Protein 31 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosome |
| Alternative Antibody Names | Anti-F-Box Only Protein 31 antibodyAnti-FBXO31 antibodyAnti-FBX14 antibodyAnti-FBX31 antibodyAnti-PP2386 antibody |
Information sourced from Uniprot.org
