| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FBXO31 |
| Gene ID: | 79791 |
| Uniprot ID: | FBX31_HUMAN |
| Immunogen Region: | 240-539 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-539 of human FBXO31 (NP_079011.3). |
| Immunogen Sequence: | GGRQEEFRTWLREEWGRTLE DIFHEHMQELILMKFIYTSQ YDNCLTYRRIYLPPSRPDDL IKPGLFKGTYGSHGLEIVML SFHGRRARGTKITGDPNIPA GQQTVEIDLRHRIQLPDLEN QRNFNELSRIVLEVRERVRQ EQQEGGHEAGEGRGRQGPRE SQPSPAQPRAEAPSKGPDGT PGEDGGEPGDAVAAAEQPAQ CGQGQPFVLPVGVSSRNEDY PRTCRMCFYGTGLIAGHGF |
| Tissue Specificity | Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow. |
| Post Translational Modifications | Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization. |
| Function | Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. |
| Protein Name | F-Box Only Protein 31 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-F-Box Only Protein 31 antibodyAnti-FBXO31 antibodyAnti-FBX14 antibodyAnti-FBX31 antibodyAnti-PP2386 antibody |
Information sourced from Uniprot.org
