| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-F-box only protein 22 (182-232 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FBXO22 |
| Gene ID: | 26263 |
| Uniprot ID: | FBX22_HUMAN |
| Immunogen Region: | 182-232 aa |
| Specificity: | This antibody detects endogenous levels of FBX22 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human FBX22 at the amino acid range 182-232 |
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. |
| Protein Name | F-Box Only Protein 22F-Box Protein Fbx22p44 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmMyofibrilSarcomereZ Line |
| Alternative Antibody Names | Anti-F-Box Only Protein 22 antibodyAnti-F-Box Protein Fbx22p44 antibodyAnti-FBXO22 antibodyAnti-FBX22 antibody |
Information sourced from Uniprot.org