| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FARP1 |
| Gene ID: | 10160 |
| Uniprot ID: | FARP1_HUMAN |
| Immunogen Region: | 350-550 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-550 of human FARP1 (NP_005757.1). |
| Immunogen Sequence: | YVKEGGHKKVQFERKHSKIH SIRSLASQPTELNSEVLEQS QQSTSLTFGEGAESPGGQSC RRGKEPKVSAGEPGSHPSPA PRRSPAGNKQADGAASAPTE EEEEVVKDRTQQSKPQPPQP STGSLTGSPHLSELSVNSQG GVAPANVTLSPNLSPDTKQA SPLISPLLNDQACPRTDDED EGRRKRFPTDKAYFIAKEVS T |
| Tissue Specificity | Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung. |
| Function | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses. |
| Protein Name | Ferm - Arhgef And Pleckstrin Domain-Containing Protein 1 Chondrocyte-Derived Ezrin-Like Protein Ferm - Rhogef And Pleckstrin Domain-Containing Protein 1 Pleckstrin Homology Domain-Containing Family C Member 2 Ph Domain-Containing Family C Member 2 |
| Database Links | Reactome: R-HSA-8980692 Reactome: R-HSA-9013148 Reactome: R-HSA-9013149 Reactome: R-HSA-9035034 |
| Cellular Localisation | Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Synapse Synaptosome Cytoplasm Cytosol Cell Projection Filopodium Dendrite Dendritic Spine Recruited To The Cell Membrane Via Interaction With Cadm1 |
| Alternative Antibody Names | Anti-Ferm - Arhgef And Pleckstrin Domain-Containing Protein 1 antibody Anti-Chondrocyte-Derived Ezrin-Like Protein antibody Anti-Ferm - Rhogef And Pleckstrin Domain-Containing Protein 1 antibody Anti-Pleckstrin Homology Domain-Containing Family C Member 2 antibody Anti-Ph Domain-Containing Family C Member 2 antibody Anti-FARP1 antibody Anti-CDEP antibody Anti-PLEKHC2 antibody |
Information sourced from Uniprot.org