| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FANCL |
| Gene ID: | 55120 |
| Uniprot ID: | FANCL_HUMAN |
| Immunogen Region: | 1-255 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human FANCL (NP_060532.2). |
| Immunogen Sequence: | MAVTEASLLRQCPLLLPQNR SKTVYEGFISAQGRDFHLRI VLPEDLQLKNARLLCSWQLR TILSGYHRIVQQRMQHSPDL MSFMMELKMLLEVALKNRQE LYALPPPPQFYSSLIEEIGT LGWDKLVYADTCFSTIKLKA EDASGREHLITLKLKAKYPA ESPDYFVDFPVPFCASWTPQ SSLISIYSQFLAAIESLKAF WDVMDEIDEKTWVLEPEKPP RSATARRIALGNNVSINIE |
| Post Translational Modifications | The RING-type zinc finger domain is monoubiquitinated in the presence of UBE2T and UBE2W. |
| Function | Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. |
| Protein Name | E3 Ubiquitin-Protein Ligase Fancl Fanconi Anemia Group L Protein Fanconi Anemia-Associated Polypeptide Of 43 Kda Faap43 Ring-Type E3 Ubiquitin Transferase Fancl |
| Database Links | Reactome: R-HSA-6783310 Reactome: R-HSA-9833482 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Fancl antibody Anti-Fanconi Anemia Group L Protein antibody Anti-Fanconi Anemia-Associated Polypeptide Of 43 Kda antibody Anti-Faap43 antibody Anti-Ring-Type E3 Ubiquitin Transferase Fancl antibody Anti-FANCL antibody Anti-PHF9 antibody |
Information sourced from Uniprot.org