Anti-FANCI antibody (STJA0007930)

SKU:
STJA0007930
£48.00 - £252.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Fanconi anemia group I protein is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FANCI
Gene ID: 55215
Uniprot ID: FANCI_HUMAN
Specificity: This antibody detects endogenous levels of FANCI at Human, Mouse
Immunogen: Synthesized peptide derived from human FANCI
Function Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage.
Protein Name Fanconi Anemia Group I Protein
Protein Faci
Database Links Reactome: R-HSA-6783310
Reactome: R-HSA-6796648
Cellular Localisation Nucleus
Cytoplasm
Observed In Spots Localized In Pairs On The Sister Chromatids Of Mitotic Chromosome Arms And Not Centromeres
One On Each Chromatids
These Foci Coincide With Common Fragile Sites
They Are Frequently Interlinked Through Blm-Associated Ultra-Fine Dna Bridges
Alternative Antibody Names Anti-Fanconi Anemia Group I Protein antibody
Anti-Protein Faci antibody
Anti-FANCI antibody
Anti-KIAA1794 antibody

Information sourced from Uniprot.org

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