| Post Translational Modifications | Monoubiquitinated by FANCL on Lys-523 during S phase and upon genotoxic stress. Deubiquitinated by USP1 as cells enter G2/M, or once DNA repair is completed. Monoubiquitination requires the FANCA-FANCB-FANCC-FANCE-FANCF-FANCG-FANCM complex. Ubiquitination is required for binding to chromatin, DNA repair, and normal cell cycle progression. Monoubiquitination is stimulated by DNA-binding. Phosphorylated in response to DNA damage by ATM and/or ATR. Phosphorylation of FANCI promotes ubiquitination of FANCD2, which prevents DNA release from the FANCI-FANCD2 complex. |
| Function | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage.this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA. Participates in S phase and G2 phase checkpoint activation upon DNA damage. |
| Protein Name | Fanconi Anemia Group I ProteinProtein Faci |
| Database Links | Reactome: R-HSA-6783310Reactome: R-HSA-6796648 |
| Cellular Localisation | NucleusCytoplasmObserved In Spots Localized In Pairs On The Sister Chromatids Of Mitotic Chromosome Arms And Not CentromeresOne On Each ChromatidsThese Foci Coincide With Common Fragile SitesThey Are Frequently Interlinked Through Blm-Associated Ultra-Fine Dna Bridges |
| Alternative Antibody Names | Anti-Fanconi Anemia Group I Protein antibodyAnti-Protein Faci antibodyAnti-FANCI antibodyAnti-KIAA1794 antibody |
Information sourced from Uniprot.org
