| Tissue Specificity | Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). |
| Function | Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion. Isoform 2: Essential for the survival of colon cancer cells to bile acid-induced apoptosis. |
| Protein Name | GastrotropinGtFatty Acid-Binding Protein 6Ileal Lipid-Binding ProteinIlbpIntestinal 15 Kda ProteinI-15pIntestinal Bile Acid-Binding ProteinI-Babp |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-163560Reactome: R-HSA-9623433 |
| Cellular Localisation | Isoform 1: CytoplasmMembranePeripheral Membrane ProteinCytoplasmic SideIsoform 2: CytoplasmLocalized Close To Nucleus On The Apical Side Of Both Normal And Neoplastic Cells |
| Alternative Antibody Names | Anti-Gastrotropin antibodyAnti-Gt antibodyAnti-Fatty Acid-Binding Protein 6 antibodyAnti-Ileal Lipid-Binding Protein antibodyAnti-Ilbp antibodyAnti-Intestinal 15 Kda Protein antibodyAnti-I-15p antibodyAnti-Intestinal Bile Acid-Binding Protein antibodyAnti-I-Babp antibodyAnti-FABP6 antibodyAnti-ILBP antibodyAnti-ILLBP antibody |
Information sourced from Uniprot.org
