| Short Description : | Goat polyclonal antibody anti-EYA4 (N-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications: | Pep-ELISA/IHC |
| Host: | Goat |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.IHC: Paraffin embedded Human Testis and Liver. Recommended concentration: 3.75µg/ml. |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | EYA4 |
| Gene ID: | 2070 |
| Uniprot ID: | EYA4_HUMAN |
| Accession Number: | NP_004091.3; NP_742103.1; NP_742101.2; NP_001287941.1; NP_001287942.1 |
| Immunogen Region: | N-Term |
| Immunogen Sequence: | EDSQDLNEQSVKKTC |
| Function | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye. |
| Protein Name | Eyes Absent Homolog 4 |
| Database Links | Reactome: R-HSA-5693565 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Eyes Absent Homolog 4 antibodyAnti-EYA4 antibody |
Information sourced from Uniprot.org
