Anti-EWSR1 antibody (1-189) [S3MR] (STJ11102513)

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STJ11102513
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Host: Rabbit
Applications: WB/IHC-P/IF/ICC/IP/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S3MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IHC-P:1:50-1:200
IF/ICC:1:50-1:200
IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specif
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EWSR1
Gene ID: 2130
Uniprot ID: EWS_HUMAN
Immunogen Region: 1-189
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human EWSR1 (Q01844).
Immunogen Sequence: MASTDYSTYSQAAAQQGYSA YTAQPTQGYAQTTQAYGQQS YGTYGQPTDVSYTQAQTTAT YGQTAYATSYGQPPTGYTTP TAPQAYSQPVQGYGTGAYDT TTATVTTTQASYAAQSAYGT QPAYPAYGQQPAATAPTRPQ DGNKPTETSQPQSSTGGYNQ PSLGYGQSNYSYPQVPGSYP MQPVTAPPS
Tissue Specificity Ubiquitous.
Post Translational Modifications Phosphorylated.calmodulin-binding inhibits phosphorylation of Ser-266. Highly methylated on arginine residues. Methylation is mediated by PRMT1 and, at lower level by PRMT8.
Function Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.
Protein Name Rna-Binding Protein Ews
Ews Oncogene
Ewing Sarcoma Breakpoint Region 1 Protein
Cellular Localisation Nucleus
Cytoplasm
Cell Membrane
Relocates From Cytoplasm To Ribosomes Upon Ptk2b/Fak2 Activation
Alternative Antibody Names Anti-Rna-Binding Protein Ews antibody
Anti-Ews Oncogene antibody
Anti-Ewing Sarcoma Breakpoint Region 1 Protein antibody
Anti-EWSR1 antibody
Anti-EWS antibody

Information sourced from Uniprot.org