Host: | Rabbit |
Applications: | WB/IHC-P/IF/ICC/IP/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Monoclonal |
Clone ID : | S3MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specif |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | EWSR1 |
Gene ID: | 2130 |
Uniprot ID: | EWS_HUMAN |
Immunogen Region: | 1-189 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human EWSR1 (Q01844). |
Immunogen Sequence: | MASTDYSTYSQAAAQQGYSA YTAQPTQGYAQTTQAYGQQS YGTYGQPTDVSYTQAQTTAT YGQTAYATSYGQPPTGYTTP TAPQAYSQPVQGYGTGAYDT TTATVTTTQASYAAQSAYGT QPAYPAYGQQPAATAPTRPQ DGNKPTETSQPQSSTGGYNQ PSLGYGQSNYSYPQVPGSYP MQPVTAPPS |
Tissue Specificity | Ubiquitous. |
Post Translational Modifications | Phosphorylated.calmodulin-binding inhibits phosphorylation of Ser-266. Highly methylated on arginine residues. Methylation is mediated by PRMT1 and, at lower level by PRMT8. |
Function | Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Protein Name | Rna-Binding Protein EwsEws OncogeneEwing Sarcoma Breakpoint Region 1 Protein |
Cellular Localisation | NucleusCytoplasmCell MembraneRelocates From Cytoplasm To Ribosomes Upon Ptk2b/Fak2 Activation |
Alternative Antibody Names | Anti-Rna-Binding Protein Ews antibodyAnti-Ews Oncogene antibodyAnti-Ewing Sarcoma Breakpoint Region 1 Protein antibodyAnti-EWSR1 antibodyAnti-EWS antibody |
Information sourced from Uniprot.org