Anti-ESA antibody [MOC‐31] (STJ180098)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenNeuraminidase treated GLS-1 human small cell lung carcinoma cells
General Information
| Short Description | Mouse monoclonal ESA antibody for use in IHC-P in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | MOC‐31 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | Affinity purified |
| Dilution Range | 1:100‐200 |
| Formulation | Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Storage Instruction | Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C. |
Target Information
| Gene Symbol | FLOT2 |
| Gene ID | 2319 |
| Uniprot ID | FLOT2_HUMAN |
| Immunogen | Neuraminidase treated GLS-1 human small cell lung carcinoma cells |
| Specificity | Positive control: Colon carcinoma |
Additional Info
| Tissue Specificity | In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes. |
| Post Translational Modifications | ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells. |
| Function | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. |
| Protein Name | Flotillin-2Epidermal Surface AntigenEsaMembrane Component Chromosome 17 Surface Marker 1 |
| Database Links | Reactome: R-HSA-5213460Reactome: R-HSA-5675482Reactome: R-HSA-8849932Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9696264Reactome: R-HSA-9696273 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinMembraneCaveolaEndosomeLipid-AnchorMembrane-Associated Protein Of Caveolae |
| Alternative Antibody Names | Anti-Flotillin-2 antibodyAnti-Epidermal Surface Antigen antibodyAnti-Esa antibodyAnti-Membrane Component Chromosome 17 Surface Marker 1 antibodyAnti-FLOT2 antibodyAnti-ESA1 antibodyAnti-M17S1 antibody |
Information sourced from Uniprot.org