Anti-ERLIN1/2 antibody (31-80 aa) (STJ98620)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from ERLIN1/2 at the amino acid range 31-80
General Information
| Short Description | Rabbit polyclonal anti-Erlin-1 and Erlin-2 (31-80 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:10000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ERLIN2ERLIN1 |
| Gene ID | 1116010613 |
| Uniprot ID | ERLN2_HUMANERLN1_HUMAN |
| Immunogen | Synthesized peptide derived from ERLIN1/2 at the amino acid range 31-80 |
| Immunogen Region | 31-80 aa |
| Specificity | ERLIN1/2 Polyclonal Antibody detects endogenous levels of ERLIN1/2 |
Additional Info
| Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex. (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production. |
| Protein Name | Erlin-1Endoplasmic Reticulum Lipid Raft-Associated Protein 1Protein Ke04Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 1Spfh Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5678895 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinAssociated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Erlin-1 antibodyAnti-Endoplasmic Reticulum Lipid Raft-Associated Protein 1 antibodyAnti-Protein Ke04 antibodyAnti-Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 1 antibodyAnti-Spfh Domain-Containing Protein 1 antibodyAnti-ERLIN1 antibodyAnti-C10orf69 antibodyAnti-KE04 antibodyAnti-KEO4 antibodyAnti-SPFH1 antibody |
Information sourced from Uniprot.org