Anti-EPHA5 antibody (471-520 aa) (STJ92944)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human EPHA5 at the amino acid range 471-520
General Information
| Short Description | Rabbit polyclonal anti-Ephrin type-A receptor 5 (471-520 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EPHA5 |
| Gene ID | 2044 |
| Uniprot ID | EPHA5_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human EPHA5 at the amino acid range 471-520 |
| Immunogen Region | 471-520 aa |
| Specificity | EphA5 Polyclonal Antibody detects endogenous levels of EphA5 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose, inhibits EPHA5 forward signaling and results in insulin secretion. |
| Function | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. |
| Protein Name | Ephrin Type-A Receptor 5Brain-Specific KinaseEph Homology Kinase 1Ehk-1Eph-Like Kinase 7Ek7Hek7 |
| Database Links | Reactome: R-HSA-2682334Reactome: R-HSA-3928663Reactome: R-HSA-3928665 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxonDendrite |
| Alternative Antibody Names | Anti-Ephrin Type-A Receptor 5 antibodyAnti-Brain-Specific Kinase antibodyAnti-Eph Homology Kinase 1 antibodyAnti-Ehk-1 antibodyAnti-Eph-Like Kinase 7 antibodyAnti-Ek7 antibodyAnti-Hek7 antibodyAnti-EPHA5 antibodyAnti-BSK antibodyAnti-EHK1 antibodyAnti-HEK7 antibodyAnti-TYRO4 antibody |
Information sourced from Uniprot.org