Anti-EP400 antibody (2057-2107 aa) (STJ196621)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human EP400 at the amino acid range 2057-2107
General Information
| Short Description | Rabbit polyclonal anti-E1A-binding protein p400 (2057-2107 aa) for use in IHC and IF in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EP400 |
| Gene ID | 57634 |
| Uniprot ID | EP400_HUMAN |
| Immunogen | Synthesized peptide derived from the human EP400 at the amino acid range 2057-2107 |
| Immunogen Region | 2057-2107 aa |
| Specificity | This antibody detects endogenous levels of EP400 at Human/Mouse |
Additional Info
| Function | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. |
| Protein Name | E1a-Binding Protein P400Cag Repeat Protein 32Domino HomologHdominoTrinucleotide Repeat-Containing Gene 12 ProteinP400 Kda Swi2/Snf2-Related Protein |
| Database Links | Reactome: R-HSA-2559584Reactome: R-HSA-2559586Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-E1a-Binding Protein P400 antibodyAnti-Cag Repeat Protein 32 antibodyAnti-Domino Homolog antibodyAnti-Hdomino antibodyAnti-Trinucleotide Repeat-Containing Gene 12 Protein antibodyAnti-P400 Kda Swi2/Snf2-Related Protein antibodyAnti-EP400 antibodyAnti-CAGH32 antibodyAnti-KIAA1498 antibodyAnti-KIAA1818 antibodyAnti-TNRC12 antibody |
Information sourced from Uniprot.org