Anti-EIF2B5 antibody (1-100) [S0MR] (STJ11102350)

Name: Anti-EIF2B5 antibody (1-100) [S0MR] (STJ11102350)
SKU: STJ11102350
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11102350

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Short Description	Rabbit monoclonal eIF2B epsilon (1-100) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	S0MR
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	EIF2B5
Gene ID	8893
Uniprot ID	EI2BE_HUMAN
Immunogen Region	1-100
Immunogen Sequence	MAAPVVAPPGVVVSRANKRS GAGPGGSGGGGARGAEEEPP PPLQAVLVADSFDRRFFPIS KDQPRVLLPLANVALIDYTL EFLTATGVQETFVFCCWKAA
Specificity	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human eIF2B epsilon (EIF2B5) (EIF2B5) (Q13144).

Post Translational Modifications	Phosphorylated at Ser-544 by DYRK2.this is required for subsequent phosphorylation by GSK3B. Phosphorylated on serine and threonine residues by GSK3B.phosphorylation inhibits its function. Polyubiquitinated, probably by NEDD4.
Function	Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Protein Name	Translation Initiation Factor Eif2b Subunit Epsilon Eif2b Gdp-Gtp Exchange Factor Subunit Epsilon
Database Links	Reactome: R-HSA-72731
Cellular Localisation	Cytoplasm Cytosol
Alternative Antibody Names	Anti-Translation Initiation Factor Eif2b Subunit Epsilon antibody Anti-Eif2b Gdp-Gtp Exchange Factor Subunit Epsilon antibody Anti-EIF2B5 antibody Anti-EIF2BE antibody

Information sourced from Uniprot.org