| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specif |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EIF2B2 |
| Gene ID: | 8892 |
| Uniprot ID: | EI2BB_HUMAN |
| Immunogen Region: | 1-120 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human EIF2B2 (NP_055054.1). |
| Immunogen Sequence: | MPGSAAKGSELSERIESFVE TLKRGGGPRSSEEMARETLG LLRQIITDHRWSNAGELMEL IRREGRRMTAAQPSETTVGN MVRRVLKIIREEYGRLHGRS DESDQQESLHKLLTSGGLNE |
| Function | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed. |
| Protein Name | Translation Initiation Factor Eif2b Subunit BetaS20i15S20iii15Eif2b Gdp-Gtp Exchange Factor Subunit Beta |
| Database Links | Reactome: R-HSA-72731 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Translation Initiation Factor Eif2b Subunit Beta antibodyAnti-S20i15 antibodyAnti-S20iii15 antibodyAnti-Eif2b Gdp-Gtp Exchange Factor Subunit Beta antibodyAnti-EIF2B2 antibodyAnti-EIF2BB antibody |
Information sourced from Uniprot.org