| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DVL1 |
| Gene ID: | 1855 |
| Uniprot ID: | DVL1_HUMAN |
| Immunogen Region: | 510-640 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 510-640 of human DVL1 (NP_004412.2). |
| Immunogen Sequence: | GQGYPYQYPGPPPCFPPAYQ DPGFSYGSGSTGSQQSEGSK SSGSTRSSRRAPGREKERRA AGAGGSGSESDHTAPSGVGS SWRERPAGQLSRGSSPRSQA SATAPGLPPPHPTTKAYTVV GGPPGGPPVRE |
| Post Translational Modifications | Ubiquitinated.undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. |
| Function | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| Protein Name | Segment Polarity Protein Dishevelled Homolog Dvl-1 Dishevelled-1 Dsh Homolog 1 |
| Database Links | Reactome: R-HSA-201681 Reactome: R-HSA-201688 Reactome: R-HSA-4086400 Reactome: R-HSA-4641258 Reactome: R-HSA-4641262 Reactome: R-HSA-5368598 Reactome: R-HSA-5663220 Reactome: R-HSA-9673324 |
| Cellular Localisation | Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Cytoplasm Cytosol Cytoplasmic Vesicle Localizes At The Cell Membrane Upon Interaction With Frizzled Family Members |
| Alternative Antibody Names | Anti-Segment Polarity Protein Dishevelled Homolog Dvl-1 antibody Anti-Dishevelled-1 antibody Anti-Dsh Homolog 1 antibody Anti-DVL1 antibody |
Information sourced from Uniprot.org