| Post Translational Modifications | Ubiquitinated.undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. |
| Function | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| Protein Name | Segment Polarity Protein Dishevelled Homolog Dvl-1Dishevelled-1Dsh Homolog 1 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-201688Reactome: R-HSA-4086400Reactome: R-HSA-4641258Reactome: R-HSA-4641262Reactome: R-HSA-5368598Reactome: R-HSA-5663220Reactome: R-HSA-9673324 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytosolCytoplasmic VesicleLocalizes At The Cell Membrane Upon Interaction With Frizzled Family Members |
| Alternative Antibody Names | Anti-Segment Polarity Protein Dishevelled Homolog Dvl-1 antibodyAnti-Dishevelled-1 antibodyAnti-Dsh Homolog 1 antibodyAnti-DVL1 antibody |
Information sourced from Uniprot.org
