| Short Description : | Rabbit polyclonal DUSP4 (1-168) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DUSP4 |
| Gene ID: | 1846 |
| Uniprot ID: | DUS4_HUMAN |
| Immunogen Region: | 1-168 |
| Immunogen Sequence: | MVTMEELREMDCSVLKRLMN RDENGGGAGGSGSHGTLGLP SGGKCLLLDCRPFLAHSAGY ILGSVNVRCNTIVRRRAKGS VSLEQILPAEEEVRARLRSG LYSAVIVYDERSPRAESLRE DSTVSLVVQALRRNAERTDI CLLKGGYERFSSEYPEFCSK TKALAAIP |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human DUSP4 (NP_001385.1). |
| Post Translational Modifications | Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein. |
| Function | Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. |
| Protein Name | Dual Specificity Protein Phosphatase 4Dual Specificity Protein Phosphatase Hvh2Mitogen-Activated Protein Kinase Phosphatase 2Map Kinase Phosphatase 2Mkp-2 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-202670Reactome: R-HSA-5675221 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 4 antibodyAnti-Dual Specificity Protein Phosphatase Hvh2 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 2 antibodyAnti-Map Kinase Phosphatase 2 antibodyAnti-Mkp-2 antibodyAnti-DUSP4 antibodyAnti-MKP2 antibodyAnti-VH2 antibody |
Information sourced from Uniprot.org
