Anti-DUSP4 antibody (1-168) (STJ23443)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DUSP4 (1-168) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DUSP4 |
| Gene ID | 1846 |
| Uniprot ID | DUS4_HUMAN |
| Immunogen Region | 1-168 |
| Immunogen Sequence | MVTMEELREMDCSVLKRLMN RDENGGGAGGSGSHGTLGLP SGGKCLLLDCRPFLAHSAGY ILGSVNVRCNTIVRRRAKGS VSLEQILPAEEEVRARLRSG LYSAVIVYDERSPRAESLRE DSTVSLVVQALRRNAERTDI CLLKGGYERFSSEYPEFCSK TKALAAIP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human DUSP4 (NP_001385.1). |
Additional Info
| Post Translational Modifications | Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein. |
| Function | Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. |
| Protein Name | Dual Specificity Protein Phosphatase 4Dual Specificity Protein Phosphatase Hvh2Mitogen-Activated Protein Kinase Phosphatase 2Map Kinase Phosphatase 2Mkp-2 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-202670Reactome: R-HSA-5675221 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 4 antibodyAnti-Dual Specificity Protein Phosphatase Hvh2 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 2 antibodyAnti-Map Kinase Phosphatase 2 antibodyAnti-Mkp-2 antibodyAnti-DUSP4 antibodyAnti-MKP2 antibodyAnti-VH2 antibody |
Information sourced from Uniprot.org