| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DUSP22 |
| Gene ID: |
56940 |
| Uniprot ID: |
DUS22_HUMAN |
| Immunogen Region: |
1-184 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human DUSP22 (NP_064570.1). |
| Immunogen Sequence: |
MGNGMNKILPGLYIGNFKDA RDAEQLSKNKVTHILSVHDS ARPMLEGVKYLCIPAADSPS QNLTRHFKESIKFIHECRLR GESCLVHCLAGVSRSVTLVI AYIMTVTDFGWEDALHTVRA GRSCANPNVGFQRQLQEFEK HEVHQYRQWLKEEYGESPLQ DAEEAKNILAAPGILKFWAF LRRL |
| Tissue Specificity | Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas. |
| Post Translational Modifications | Myristoylation regulates subcellular location, and is necessary for activation of JNK. |
| Function | Dual specificity phosphatase.can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Activates the JNK signaling pathway. Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2. Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2. Dephosphorylates and thereby inactivates tyrosine kinase LCK. Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK. May play a role in B-cell receptor (BCR) signaling and B-cell function. |
| Protein Name | Dual Specificity Protein Phosphatase 22Jnk Pathway Associated PhosphataseJkapJnk-Stimulatory Phosphatase-1Jsp-1Low Molecular Weight Dual Specificity Phosphatase 2Lmw-Dsp2Mitogen-Activated Protein Kinase Phosphatase XMap Kinase Phosphatase XMkp-X |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 22 antibodyAnti-Jnk Pathway Associated Phosphatase antibodyAnti-Jkap antibodyAnti-Jnk-Stimulatory Phosphatase-1 antibodyAnti-Jsp-1 antibodyAnti-Low Molecular Weight Dual Specificity Phosphatase 2 antibodyAnti-Lmw-Dsp2 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase X antibodyAnti-Map Kinase Phosphatase X antibodyAnti-Mkp-X antibodyAnti-DUSP22 antibodyAnti-JSP1 antibodyAnti-LMWDSP2 antibodyAnti-MKPX antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
