| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Dual oxidase 1 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments in Human Placenta and Thyroid Gland lysates gave no specific signal but low background (at antibody concentration up to 0.5µg/ml). We would appreciate any feedb |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | DUOX1 |
| Gene ID: | 53905 |
| Uniprot ID: | DUOX1_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_059130.2 ; NP_787954.1 |
| Specificity: | This antibody is expected to recognise both reported isoforms (NP_059130.2 ; NP_787954.1) which are identical;Concentration=0.5 mg/mL" |
| Immunogen Sequence: | EKFQRSCLHQTVQ |
| Post Translational Modifications | N-glycosylated. |
| Function | Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. |
| Protein Name | Dual Oxidase 1Large Nox 1Long Nox 1Nadph Thyroid Oxidase 1Thyroid Oxidase 1 |
| Database Links | Reactome: R-HSA-209968 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinLocalizes To The Apical Membrane Of Epithelial Cells |
| Alternative Antibody Names | Anti-Dual Oxidase 1 antibodyAnti-Large Nox 1 antibodyAnti-Long Nox 1 antibodyAnti-Nadph Thyroid Oxidase 1 antibodyAnti-Thyroid Oxidase 1 antibodyAnti-DUOX1 antibodyAnti-DUOX antibodyAnti-LNOX1 antibodyAnti-THOX1 antibody |
Information sourced from Uniprot.org