Anti-DTX1 antibody (1-190) (STJ11103349)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DTX1 (1-190) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DTX1 |
| Gene ID | 1840 |
| Uniprot ID | DTX1_HUMAN |
| Immunogen Region | 1-190 |
| Immunogen Sequence | MSRPGHGGLMPVNGLGFPPQ NVARVVVWEWLNEHSRWRPY TATVCHHIENVLKEDARGSV VLGQVDAQLVPYIIDLQSMH QFRQDTGTMRPVRRNFYDPS SAPGKGIVWEWENDGGAWTA YDMDICITIQNAYEKQHPWL DLSSLGFCYLIYFNSMSQMN RQTRRRRRLRRRLDLAYPLT VGSIPKSQSW |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human DTX1 (NP_004407.2). |
Additional Info
| Tissue Specificity | Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells. |
| Post Translational Modifications | Ubiquitinated.undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH. |
| Function | Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Dtx1Protein Deltex-1Deltex1Hdtx1Ring-Type E3 Ubiquitin Transferase Dtx1 |
| Database Links | Reactome: R-HSA-2122948 |
| Cellular Localisation | CytoplasmNucleusPredominantly CytoplasmicAssociates With Endocytic VesiclesPartially Nuclear |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Dtx1 antibodyAnti-Protein Deltex-1 antibodyAnti-Deltex1 antibodyAnti-Hdtx1 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Dtx1 antibodyAnti-DTX1 antibody |
Information sourced from Uniprot.org